ORCHARD PARK, N.Y. -- Guard Richie Incognito knew LeSean McCoys right knee was fine when the Bills running back was already gabbing in Buffalos locker room during halftime.As long as Shadys talking, hes fine, Incognito said.If knocking knees with 49ers linebacker Nick Bellore late in the first half couldnt slow down the player nicknamed, Shady, what chance did the 49ers porous run defense have?McCoy had 140 yards rushing and matched a career high by scoring three times, and the Bills extended their winning streak to four with a 45-16 victory over San Francisco and new starter Colin Kaepernick Sunday.Buffalo fans greeted Kaepernick roughly for his leadership among athletes protesting during the national anthem. They booed him loudly, sold anti-Kaepernick T-shirts and roughed up a dummy wearing his jersey.Kaepernick finished 13 of 29 for 187 yards, including a 53-yard touchdown pass to Torrey Smith. But San Francisco (1-5) couldnt finish drives, settling for three field goals by Phil Dawson, in losing its fifth straight game.I thought he was OK, coach Chip Kelly said of Kaepernick, whom he promoted over Blaine Gabbert following a 33-21 loss to Arizona. But overall, offensively as a group, we need to run the ball better and we need to be better at the passing game.Kelly wouldnt commit to who will start next week against Tampa Bay.Yeah, well see, he said.Tyrod Taylor threw two touchdown passes in helping Buffalo win four straight for the first time since the start of the 2008 season.The 49ers allowed 312 yards rushing -- Buffalos best outing since 1992. The defense has allowed 981 yards on the ground in its past five games.The Bills blew the game open by scoring 21 points over a span of 7:02 straddling the third and fourth quarters.Taylor completed a 30-yard pass to Justin Hunter . Then the 49ers were stopped for no gain on a fourth-and-1 at Buffalos 40.After McCoy put the Bills up 31-16 with 10:53 left in the fourth quarter, the Bills got the ball back on after Keshawn Martin fumbled the kickoff.Two plays later, Taylor hit Robert Woods for a 5-yard touchdown pass.McCoy scored twice on 18-yard runs and another on a 4-yard scamper in his second meeting against Kelly. McCoy expressed bitter feelings toward Kelly for trading him from Philadelphia to Buffalo.To sit here and tell you that it didnt affect me last year, I would be lying, McCoy said. But Im past that. Its a whole year later.HAT-TRICKMcCoys 3-TD game was the third of his career, and first since Philadelphias 45-19 win over the Rex Ryan-coached Jets in 2011. He became Buffalos first player to score three times rushing since Willis McGahee had four TDs against Seattle in 2004.Backup Mike Gillislee closed out the scoring with a 44-yard run. Buffalos 45 points were the most since a 49-31 win at Cincinnati in 2010.RYANS DBills LB Lorenzo Alexander extended his sack streak to six games, matching the teams longest since Aaron Schobel did it during the 2006 season. The 10-year journeyman now has eight sacks this year.With three sacks on Sunday, Buffalo upped its total to 20 -- one fewer than the team had all last season.KAEPERNICK PROTESTFans chanted USA! USA! USA! shortly before Kaepernick knelt for the anthem.To be honest, I was focused on football so I really wasnt listening to what was going on in the stands, Kaepernick said.Outside New Era Field, one vendor was selling T-shirts against Kaepernick.INJURIES49ers: RB Carlos Hyde (shoulder), CB Rashard Robinson (concussion protocol).Bills: TE Charles Clay (ankle), WR Kevon Seymour (shoulder) and WR Robert Woods (right foot).BLOWN COVERAGEBuffalos defensive backfield left Smith wide open in scoring on his 53-yard catch and run . Cornerback Stephon Gilmore let Smith blow past him at the line of scrimmage leaving Smith open up the right sideline. He easily caught Kaepernicks pass and then cut into the middle to avoid being tackled by safety Aaron Williams who was Buffalos only defender deep.NEXT UP:49ers: Host Tampa Bay on Oct. 23.Bills: Play at AFC East rival Miami on Oct. 23.---AP NFL website: www.pro32.ap.org and http://twitter.com/AP-NFLAdidas Deerupt Runner Rea .C. -- Manny Malhotra had two goals and an assist, leading the Carolina Hurricanes to a 6-3 win over the Ottawa Senators on Saturday. NMD Bape Sverige . -- Damian Lillard and LaMarcus Alrdridge were again the go-to duo for the Trail Blazers against the Kings. http://www.nmdsverige.com/nmd-r2-adidas-skor.html . How great will be revealed in the next couple of days at the board of governors meeting in Pebble Beach, Calif. Adidas NMD R1 Rabatt . Scott Kazmir allowed four hits in seven shutout innings, Michael Brantley hit a two-run homer in a three-run first inning and the Indians maintained their hold on an AL wild-card spot with a 4-1 win over the Houston Astros on Saturday night. NMD Skor Sverige .7 million, one-year contract, a raise of $2.2 million. Wieters had asked for $8.75 million and the Orioles had offered $6.The Ottawa Senators have s re-signed forward Stephane Da Costa to a one-year, two-way contract. Da Costa, 24, spend the majority of the 2012-13 season with the American Hockey Leagues Binghamton Senators, sharing the team lead with 38 points (including 13 goals). He also appeared in nine games with Ottawa, scoring once and adding one assist.dddddddddddd In 35 career National Hockey League games, Da Costa has scored four goals, while adding three assists and eight penalty minutes. Da Costa was originally signed by the Senators as an undrafted college free agent on March 31, 2011, after two NCAA seasons with Hockey Easts Merrimack College. ' ' '